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Issues with Peyronie’s Disease? Explore Nonsurgical Treatment Options

December 19, 2025

Urologist consultation for male patient for nonsurgical treatment for Peyronie's disease.

Nonsurgical treatment for Peyronie’s disease provides hope for men seeking to address penile curvature without undergoing invasive procedures. This condition affects approximately 3-9% of men, causing curved erections that can lead to pain and difficulty with sexual intercourse.

Understanding your treatment options is crucial for making informed decisions about your health. Many patients find significant improvement through conservative approaches before considering surgical intervention.

In short, nonsurgical treatment for Peyronie’s disease offers effective alternatives to surgery for many men experiencing penile curvature and erectile dysfunction.

  • Conservative management – Oral medications and vitamin therapy can reduce plaque formation.
  • Injection therapy – Targeted treatments directly into penile plaques show promising results.
  • Traction devices – Mechanical stretching helps improve curvature and length.

What is Peyronie’s Disease?

Peyronie’s disease occurs when fibrous scar tissue, called plaque, develops under the skin of the penis. This plaque formation causes the penis to curve during erections, which may result in pain and erectile dysfunction.

The exact cause remains unclear, but researchers believe trauma or injury to the penis may trigger the condition. According to the Mayo Clinic, the disease progresses through two phases: an acute inflammatory phase lasting 12-18 months, followed by a chronic stable phase.

During the acute phase, pain typically accompanies erections and the curvature may worsen. The chronic phase involves less pain but stabilized curvature that rarely improves without intervention.

Who Should Consider Nonsurgical Treatment for Peyronie’s Disease?

Most urologists recommend conservative management as the first-line approach for Peyronie’s disease. Patients with mild curvature, minimal pain, or those in the acute phase often benefit from nonsurgical treatments.

Men who can still engage in sexual intercourse despite some curvature may find nonsurgical approaches sufficient. These treatments work best when started early in the disease process.

Candidates for conservative management typically have curvature less than 60 degrees and adequate erectile function. However, each case requires individual assessment by a qualified urologist.

What Are the Main Nonsurgical and Minimally Invasive Treatment Options?

The most common nonsurgical treatments for Peyronie’s disease are:

Oral Medications

Several oral medications have shown promise in treating Peyronie’s disease. Potassium para-aminobenzoate (Potaba) has been used for decades, though evidence for its effectiveness remains limited.

Pentoxifylline improves blood flow and may help reduce plaque size. L-arginine and other supplements are sometimes prescribed, but patients should consult their urologist before starting any oral treatment regimen.

Intralesional Injection Therapy

Injectable treatments deliver medication directly into the penile plaque.

  • Collagenase clostridium histolyticum (Xiaflex) is the only FDA-approved injection for Peyronie’s disease. Xiaflex can reduce curvature by approximately 17 degrees on average. The treatment involves a series of injections administered over several months.
  • Verapamil injections represent another option. This calcium channel blocker may help soften plaques and reduce curvature when injected directly into affected tissue.
  • Interferon alpha-2b has also shown promise in clinical trials. This treatment may help reduce plaque size and improve penile curvature in some patients.

Mechanical Traction Devices

Penile traction therapy uses gentle stretching to improve length and reduce curvature. These devices apply controlled force to gradually remodel penile tissue.

Studies suggest that traction therapy can improve penile length and reduce curvature when used consistently. Patients typically wear the device for several hours daily over several months.

RestoreX and other FDA-cleared devices provide structured treatment protocols. These mechanical approaches work best when combined with other conservative treatments.

Vacuum Therapy

Vacuum erection devices create negative pressure to draw blood into the penis. This therapy may help maintain erectile function and potentially reduce curvature progression.

Regular use of vacuum therapy can help preserve penile length and improve blood flow. Some patients find this treatment helpful as part of a comprehensive management plan.

The treatment for erection problems often includes vacuum therapy as a supportive measure alongside other interventions.

What Should You Expect During Treatment?

Most nonsurgical treatments require several months to show significant results. Patients need realistic expectations about treatment timelines and potential outcomes.

Injectable therapies are minimally invasive and typically involve multiple office visits over 3-6 months. Side effects may include temporary swelling, bruising, or discomfort at injection sites.

Traction therapy requires daily commitment and a gradual increase in wearing time. Initial discomfort usually resolves as patients adapt to the device.

Regular follow-up appointments allow urologists to monitor progress and adjust treatment plans as needed.

When Should You Consider Surgery?

Surgery becomes an option when nonsurgical treatments fail to provide adequate improvement. Severe curvature preventing sexual intercourse may require surgical correction.

Surgical options include penile plication, plaque incision with grafting, or penile implant placement. Each procedure has specific risks and benefits that require careful consideration.

A urologist can evaluate your specific situation and recommend the most appropriate treatment approach based on your individual needs.

Are There Lifestyle Modifications That Help?

Maintaining overall cardiovascular health supports erectile function and may slow disease progression. Regular exercise, a healthy diet, and smoking cessation benefit penile health.

Managing underlying conditions like diabetes or high blood pressure helps optimize treatment outcomes. Stress reduction techniques may also provide some benefit.

Some men find that gentle penile massage or stretching exercises help maintain flexibility, though medical evidence for these approaches remains limited.

Finding Expert Nonsurgical Treatment for Peyronie’s Disease in Phoenix, AZ

Nonsurgical options offer hope for many men with Peyronie’s disease. Early intervention with conservative treatments can prevent progression and improve quality of life significantly.

Our urology specialist at Ironwood Urology, Dr. Avila, provides comprehensive evaluation and personalized treatment plans for Peyronie’s disease. Our experienced team offers the latest nonsurgical therapies in a comfortable, confidential environment.

Do not let Peyronie’s disease control your life. Contact Ironwood Urology today at (480) 961-2323 or request an appointment online to discuss your treatment options and take the first step toward recovery.

Filed Under: General, Peyronie's Disease Tagged With: Cardiovascular Health, Erectile Dysfunction, Minimally Invasive Treatment, non surgical treatment for peyronie's disease, penile curvature, Penile Traction Therapy, treatment for erection problem, Urologist near Me, urology specialist

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Dr. Avila focuses on all aspects of men's health, including vasectomy, vasectomy reversal, male infertility, low testosterone, erectile dysfunction, penile prosthetic surgery, Peyronie’s disease, prostate health, and robotic urological surgery.